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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: Bioorg Med Chem. 2017 Dec 5;26(6):1179–1188. doi: 10.1016/j.bmc.2017.11.047

Figure 1.

Figure 1

(A) Illustration of LUBAC structural domains. The HOIP-UBA/HOIL-UBL interaction is indicated. (B) Crystal structure of the HOIP-UBA/HOIL-UBL interaction (PDB: 4DBG). UBA – beige, UBL – green. Red indicates key residues for binding, blue indicates P619. (B) Circular dichroism spectra in H2O of peptides presented in this work (50 μM peptide concentration).