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. 2018 Mar 9;8:4230. doi: 10.1038/s41598-018-22600-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Target activation of KIBRA promoter P1a by ZFP226. Luciferase-based reporter experiments with ZFP226 co-expression resulted in a significant activation of KIBRA promoter P1a (constructs −316/+186 and −730/+186) compared to pcDNA3.1 mock-control. Site-directed mutagenesis (construct −730/+186 M) prevented the ZFP226 effect. Promoter activity of KIBRA reporter constructs was determined as relative light units and expressed as FI compared to mock-transfection. Transfections are representative for experiments (n = 4). ***p < 0.001; ns, not significant.