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. 2018 Mar 9;8:4239. doi: 10.1038/s41598-018-19993-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Preprocessing of the T₁ Map Acquired with 7 T MP2RAGE. Preprocessing included (A) skull stripping and within-subject alignment of the T₁ maps, (B) automated delineation of hippocampal subfields, and (C) estimation of median T₁ relaxation time for each hippocampal subfield. Note that within-subject alignment of time points T1, T2, and T3 is not shown as it resembled the procedure for time point T0, respectively. MR images refer to an exemplary sagittal view of a single subject for illustrative purposes. FLIRT = FMRIB’s Linear Image Registration Tool, MP2RAGE = magnetization-prepared two rapid acquisition gradient echoes, MR = Magnetic Resonance, STAPLE = simultaneous truth and performance level estimation, SyN = symmetric normalization method, TP = time point.