Table 3.
Effect of Irbesartan on inflammatory changes induced by indomethacin in rat gastric mucosa.
| Groups | COX-2 (Relative mRNA expression) | PGE-2 (ng/g tissue) | TNF-α (pg/g tissue) | IL-4 (pg/g tissue) |
|---|---|---|---|---|
| Normal | 1 ± 0.02 | 10.86 ± 0.18 | 5.48 ± 0.07 | 41.72 ± 0.51 |
| Irb | 1.12 ± 0.01 | 10.63 ± 0.18 | 5.27 ± 0.03 | 42.25 ± 0.61 |
| Ind | 1.86 ± 0.01★ | 23.28 ± 1.48★ | 13.07 ± 1.01★ | 77.64 ± 2.56★ |
| Ind + Ran | 1.38 ± 0.01★@ | 15.27 ± 0.34★@ | 6.89 ± 0.09@ | 63.22 ± 0.73★@ |
| Ind + Irb | 1.46 ± 0.01★@ | 16.38 ± 0.47★@ | 8.19 ± 0.20★@ | 73.88 ± 0.67★ |
Each value represents the mean ± S.E.M. of 6 rats. *vs normal, @vs Ind (one-way ANOVA followed by Tukey’s multiple comparisons test; p < 0.05). Irb, Irbesartan; Ind, indomethacin, Ran, ranitidine.