Table 2.

Anti-proliferative activity of the benzofurane derivatives in A2780 and A2780 AD cell lines.

Comp.	A2780 IC50 (μM)a	A2780 AD IC50 (µM)a	R/S indexb
8	0.116 ± 0.008	0.111 ± 0.016	0.96
20	0.44 ± 0.02	0.66 ± 0.05	1.49
27	0.023 ± 0.002	0.039 ± 0.015	1.70
28	0.038 ± 0.007	0.076 ± 0.015	2.00
Podophilotoxin	0.064 ± 0.009	0.074 ± 0.012	1.15
Colchicine	0.015 ± 0.004	0.9 ± 0.072	58.9
Paclitaxel	0.001 ± 0.0001	2.1 ± 0.3	2100

^aIC₅₀ (50% inhibition of cell proliferation) values in ovarian carcinomas. IC₅₀ values are given as the mean ± standard error of three independent experiments.

^bResistance index (the relative resistance of A2780AD cell line, obtained by dividing the IC₅₀ of the resistant cell line by that of the parental A2780 cell line).