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. 2018 Mar 9;8:4277. doi: 10.1038/s41598-018-22753-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distinct patterns of allele-specific miRNAs in the postmortem prefrontal cortex (PFC) of offspring without and with ASD. (a) Parental expression pattern of miRNAs was analyzed on a genome-wide scale with RNA-Seq in the PFC of both offspring. (b) Heatmap analyses of allele-specific expression profiles for miRNAs with fold changes of >0.5 or <−0.5 on a base-10 logarithmic scale between the offspring without and with ASD. (c,d) Allele-specific expression was validated for the miRNAs in (b) from the two offspring by Sanger sequencing. SNP information is shown as (paternal allele/maternal allele). Euclidean distance was used to generate the heatmap plots.