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. 2018 Mar 9;8:4309. doi: 10.1038/s41598-018-22342-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Impaired muscle regeneration in adult Ts65Dn mice. (A) TA muscle collected from 5mo old mice, 28 days post injury, immunoreactive for Pax7 (red) to identify satellite cells and immunoreactive for laminin (green) to identify the basal lamina. DAPI is blue. Carets mark satellite cells. (B–C) Quantification shows satellite cell number (B) and average fiber cross sectional area (C) in regenerated muscle tissue of wild type and Ts65Dn mice (n = 3). Statistical significance was tested using Student’s t test. Asterisks indicates significant difference and P-value < 0.05. Scale bar is 40 μm.