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. 2018 Mar 9;8:4309. doi: 10.1038/s41598-018-22342-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Further impairment of satellite cell function in 12 month old Ts65Dn tissue. (A) Satellite cells from TA muscles collected 28 days post injury from 12 mo old mice were quantified by Pax7 immunoreactivity (red) to mark satellite cells and laminin immunoreactivity (green) to identify the basal lamina. DAPI = blue. Carets mark satellite cells. (B) Satellite cell numbers quantified at 28 days post injury muscle for Ts65Dn regenerated muscle compared to wild type muscle at 5 mo of age and 12 mo of age. (C) Myofiber cross sectional area was measured in Ts65Dn regenerated muscle and wild type regenerated muscle at 5 mo of age and 12 mo of age. Statistical significance was tested using Student’s t test. Asterisks or pound sign indicates significant difference and P-value < 0.05. NS indicates not significant. Scale bar is 40 μm.