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. 2018 Mar 5;9:187. doi: 10.3389/fphar.2018.00187

Table 2.

The potential targets and their network degrees and related pathways.

Target Description Degree Involved in pathway
PTGS2 Prostaglandin G/H synthase 2 61 TNF-α, NF-kappa B, VEGF signaling pathway
ADRB2 Beta-2 adrenergic receptor 24 cGMP-PKG, cAMP signaling pathway, Calcium
PIK3CA Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 14 PI3K-Akt, RAS signaling pathway, hepatocellular carcinoma
PPARG Peroxisome proliferator-activated receptor gamma 11 PPAR, AMPK, glucagon, Insulin signaling pathway
NF-κB p65 Nuclear factor-kappa B p65 7 TNF-α, Toll-like receptor, apoptosis, IL-17, HIF-1 signaling pathway, NAFLD, hepatitis B
Caspase3 Caspase3 7 Apoptosis – multiple species
Gsk3B Glycogen synthase kinase 3 beta 6 Cell cycle, IL-17, B cell receptor signaling pathway, hepatitis C
BAX BAX 6 Apoptosis, apoptosis – multiple species, NAFLD
AP-1 Nuclear transcription factor activation protein -1 5 TNF-α, toll-like receptor, IL-17 signaling pathway
TNF-α Tumor necrosis factor 4 TNF-α, NF-κB, mTOR, MAPK signaling pathway
AKT1 RAC-alpha serine/threonine-protein kinase 4 PI3K-Akt, mTOR, FoxO, AMPK, VEGF signaling pathway