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. 2018 Mar 5;9:321. doi: 10.3389/fimmu.2018.00321

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Copyright © 2018 Geneugelijk, Niemann, Drylewicz, van Zuilen, Joosten, Allebes, van der Meer, Hilbrands, Baas, Hack, van Reekum, Verhaar, Kamburova, Bots, Seelen, Sanders, Hepkema, Lambeck, Bungener, Roozendaal, Tilanus, Vanderlocht, Voorter, Wieten, van Duijnhoven, Gelens, Christiaans, van Ittersum, Nurmohamed, Lardy, Swelsen, van der Pant, van der Weerd, ten Berge, Bemelman, Hoitsma, van der Boog, de Fijter, Betjes, Heidt, Roelen, Claas, Otten and Spierings.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Modeling of the increased hazard on graft failure for each Predicted Indirectly ReCognizable HLA Epitopes presented by recipient HLA class II (PIRCHE-II). Based on the multivariable analyses, the kidney graft failure risk is plotted as a function of the number of PIRCHE-II for both the overall cohort and for the first-transplantations only group. For example for the overall cohort, a patient with a PIRCHE-II value of 2.718 [ln(2.718) = 1] has a hazard of 1.13 on kidney graft failure, whereas a patient with a PIRCHE-II value of 7.388 [=2.718*2.718; ln(7.388) = 2] has a hazard of 1.26 (an increase of 0.13 compared with a PIRCHE-II value of 2.718) on kidney graft failure. Similar calculations were performed for other PIRCHE-II values and for the first-transplantations only group. The differences in hazard on kidney graft failure between different PIRCHE-II values decrease for higher PIRCHE-II values.