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. 2017 Oct;125(1):41–47. doi: 10.1016/j.radonc.2017.07.033

Table 1.

Mean doses and their pairwise differences for 22 patients with early-stage mediastinal Hodgkin lymphoma in free breathing (FB) or deep inspiration breath hold (DIBH) delivered with intensity modulated radiation therapy (IMRT) or proton therapy. The Friedman test and post-hoc analysis with Bonferroni correction were used for pairwise comparisons. P-values <0.05 and <0.01 are marked with * and **, respectively. Doses are in Gy (RBE) for proton therapy. Breast dose is given for 14 female patients. ǂValve doses given as the mean dose to all heart valves: mitral, aortic, pulmonary, and tricuspid. §EQD2 valve doses are given as either the mitral or aortic valves, whichever was higher, to match what is used in the risk model. Plots of mean dose for heart, valves, LADCA, breast, and lung can be found in the supplementary material (Figs. S3–S7). Abbreviations: LADCA: left anterior descending coronary artery, EQD2: equivalent dose in 2 Gy fractions.

Metric IMRT FB (1) IMRT DIBH (2) Proton FB (3) Proton DIBH (4) Median of Pairwise Differences (Range)
Median Median Median Median
(Range) (Range) (Range) (Range) 1–2 1–3 1–4 2–3 2–4 3–4
Heart Dose (Gy) 8.0 3.6 6.1 3.7 2.1** 1.1* 2.6** −0.2 0.5 1.3**
(0.1–23.2) (0.1–17.3) (0.3–17.3) (0.3–13.6) (−0.8–8.7) (−1.0–7.8) (−0.1–13.3) (−8.0–4.0) (−0.7–7.4) (−0.5–8.4)
Valve Doseǂ (Gy) 21.0 13.4 16.7 9.5 4.7** 1.3* 5.7** −2.4 0.5 2.3*
(0.3–30.0) (0.2–28.8) (0.3–30.2) (0.3–29.1) (−3.5–14.8) (−3.0–8.5) (−3.0–24.3) (−14.7–7.6) (−3.6–10.8) (−5.8–19.4)
Valve Dose EQD2§ (Gy) 15.8 7.8 11.3 6.5 4.1** 1.2** 4.1** −0.3 0.3 0.8
(0.2–29.6) (0.1–29.6) (0.1–30.0) (0.1–30.0) (−4.0–15.5) (−0.4–13.6) (−3.3–28.2) (−13.7–10.9) (−6.7–13.1) (−7.3–19.9)
LADCA Dose (Gy) 7.7 4.7 5.2 2.9 1.4* 0.6 3.8** 0.0 0.6 1.4*
(0.1–29.5) (0.1–24.5) (0.3–29.9) (0.3–24.9) (−0.3–13.6) (−1.6–10.0) (−3.0–14.9) (−13.1–6.4) (−3.3–10.4) (−2.1–14.0)
Lung Dose (Gy) 9.8 8.0 7.0 5.7 2.3** 2.8** 4.6** 0.6 1.9** 1.2
(1.8–17.2) (1.4–12.6) (0.8–12.8) (0.9–10.3) (0.1–5.9) (0.8–5.4) (0.8–8.6) (−2.9–3.4) (0.4–3.6) (−0.6–4.5)
Breast Dose (Gy) 4.3 4.6 1.4 1.6 0.3 3.1** 3.1** 2.8** 3.4** 0.1
(0.1–14.4) (0.2–12.5) (0.3–6.3) (0.3–4.1) (−3.4–3.0) (−0.1–11.1) (−0.1–11.8) (−0.1–10.1) (−0.1–9.9) (−0.8–3.8)