Table 2.

Hazard ratios (HR), life years lost (LYL) estimates, and their pairwise differences for 22 patients with early-stage mediastinal Hodgkin lymphoma in free breathing (FB) or deep inspiration breath hold (DIBH) delivered with intensity modulated radiation therapy (IMRT) or proton therapy. The Friedman test and post-hoc analysis with Bonferroni correction were used for pairwise comparisons. P-values <0.05 and <0.01 are marked with ^* and ^**, respectively. Doses are in Gy (RBE) for proton therapy. Breast cancer HR given for 14 female patients. A plot of total LYL can be found in the supplementary material (Fig. S8).

Metric	IMRT FB (1)	IMRT DIBH (2)	Proton FB (3)	Proton DIBH (4)	Median of Pairwise Differences (Range)
	Median	Median	Median	Median
	(Range)	(Range)	(Range)	(Range)	1–2	1–3	1–4	2–3	2–4	3–4
Heart Failure HR	1.4	1.2	1.3	1.2	0.1**	0.1*	0.2**	−0.01	0.03	0.1**
	(1.01–2.6)	(1.01–2.2)	(1.01–2.2)	(1.01–2.0)	(−0.04–0.6)	(−0.1–0.5)	(−0.01–0.9)	(−0.3–0.3)	(−0.03–0.5)	(−0.02–0.4)
Myodardial Infarction HR	1.4	1.2	1.2	1.1	0.1**	0.1*	0.1**	−0.01	0.02	0.04**
	(1.005–2.0)	(1.004–1.8)	(1.01–1.7)	(1.01–1.7)	(−0.05–0.3)	(−0.04–0.3)	(0.0–0.5)	(−0.2–0.1)	(−0.04–0.3)	(−0.03–0.2)
Valvular Heart Disease HR	1.4	1.1	1.2	1.1	0.1**	0.1**	0.2**	0.0	0.0	0.01
	(1.001–2.8)	(1.001–2.8)	(1.001–2.9)	(1.001–2.9)	(−0.3–1.5)	(−0.1–1.2)	(−0.3–1.8)	(−1.2–0.8)	(−0.4–0.8)	(−0.5–0.9)
Lung Cancer HR	2.3	2.1	1.9	1.7	0.3	0.4**	0.6**	0.1	0.3**	0.2
	(1.2–3.9)	(1.2–3.2)	(1.1–3.2)	(2.0–2.8)	(0.01–1.0)	(0.1–1.4)	(0.1–1.5)	(−0.4–0.5)	(0.1–0.6)	(−0.3–0.8)
Breast Cancer HR	1.7	1.7	1.2	1.2	0.05	0.5**	0.5**	0.4**	0.5**	0.0
	(1.02–3.2)	(1.03–2.9)	(1.04–2.0)	(1.04–1.6)	(−0.5–0.5)	(−0.02–1.7)	(−0.02–1.8)	(−0.01–1.5)	(−0.01–1.5)	(−0.1–0.6)
Total LYL (years)	2.1	0.9	1.3	0.7	0.7**	0.6**	0.9**	0.02	0.1*	0.3
	(0.08–6.7)	(0.07–5.7)	(0.03–5.6)	(0.04–5.3)	(−0.8–4.1)	(0.05–3.6)	(−0.4–5.9)	(−2.9–2.3)	(−0.9–2.7)	(−1.5–3.4)