Fig. 1.

Structure of the dLGN^TPR:Insc^ASYM complex. a–d Cartoon representation of the dLGN^TPR:Insc^ASYM tetramer in three orthogonal orientations. The two protomers of dLGN^TPR are colored gold and orange, while the two Insc^ASYM are in cyan and purple. The two-fold symmetry axis of the tetramer is marked as a red oval in a. b Surface representation of the arrangement of the dLGN^TPR domains with the N-terminal fragments of Insc^ASYM-labeled PEPT (Insc^PEPT in the text) in the same orientation and colors as in a. e–h Close-up views of the interaction of Insc-A with the other subunits of the tetramer from the N terminus to the end of the polypeptide chain. The positions of the individual close-up views within the complex are indicated in d. Interacting residues at the interfaces are depicted in balls-and-sticks