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. 2018 Mar 9;8:4305. doi: 10.1038/s41598-018-22364-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time-dependent effect of B49Mod1 on cancer cell expansion in clonogenic 3D cultures. (A,B) Representative 4× images and quantification of spheres formed by (A) 4T1 cells, (B) E0771, (C) shCTL MDA-MB 231 and (D) shBST-2 MDA-MB 231 cells embedded in VitroGel 3D and treated with Vehicle or B49Mod1 (500 ng/well). Graphs show average number of spheres per field. Error bars correspond to SEM for sphere quantification. Significance was taken at **P < 0.01, ***P < 0.001 and ****P < 0.0001. ns = not significant.