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. 2018 Mar 9;8:4216. doi: 10.1038/s41598-018-22578-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Flow-charts of the proposed methodology. (a) A flow-chart of the proposed methodology for the extraction of time-dependent disease associations and (b) the unsupervised clustering method of the common disease trajectories using the DTW algorithm. A_i(N,M) denotes the final accumulated distance or global cost between the new incoming trajectory (new_traj) and each trajectory traj_i (i = i, 2, …) of the existing clusters, according to equation (2).