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. 2018 Mar 9;8:4216. doi: 10.1038/s41598-018-22578-1

Table 1.

Statistically significant comorbidity pairs in men. The thirty most frequent statistically significant pairwise comorbidities encountered in the male sub-population and their p-values. The arrow indicates preferred directionality (double arrow implies no preferred directionality). The total number of patients (#pat) sharing the diseases with either directionality is also shown. The comorbidity pairs are ordered according to the total number of patients.

Disease Association #pat P-value
Chronic bronchitis (491) → Other diseases of lung (518) 9,087 <4.9E-324
Cataract (366) → Chronic bronchitis (491) 7,749 1.9E-36
Chronic bronchitis (491) → Pneumonia (486) 7,091 <4.9E-324
Inguinal hernia (550) → Cataract (366) 6,692 3.0E-38
Acute myoc infarction (410) → Ischemic heart disease (414) 6,101 <4.9E-324
Chronic bronchitis (491) → Heart failure (428) 5,720 <4.9E-324
Cataract (366) → Other diseases of lung (518) 5,043 3.9E-9
Pneumonia (486) → Other diseases of lung (518) 4,546 <4.9E-324
Osteoarthrosis (715) → Cataract (366) 4,212 1.1E-66
Heart failure (428) → Other diseases of lung (518) 4,162 <4.9E-324
Other acute isch heart dis (411) → Ischemic heart disease (414) 4,026 <4.9E-324
Cataract (366) → Occl of cerebral arteries (434) 3,942 9.3E-18
Cataract (366) ↔ Ischemic heart disease (414) 3,915 1.6E-10
Cataract (366) → Acute myoc infarction (410) 3,902 1.2E-13
Hyperplasia of prostate (600) → Cataract (366) 3,820 4.0E-61
Cardiac dysrhythmias (427) → Heart failure (428) 3,792 <4.9E-324
Pneumonia (486) → Heart failure (428) 3,752 3.1E-258
Cataract (366) → Other dis urethra/urin tract (599) 3,578 7.6E-47
Acute myocardial infarction (410) → Heart failure (428) 3,421 <4.9E-324
Cataract (366) → Bladder cancer (188) 3,193 8.7E-13
Bladder cancer (188) → Other dis urethra/urin tract (599) 3,140 <4.9E-324
Ischemic heart disease (414) → Heart failure (428) 2,879 9.9E-190
Acute myocardial infarction (410) → Other acute isch heart dis (411) 2,870 <4.9E-324
Ac bronch (466) → Chronic bronchitis (491) 2,868 9.8E-161
Ac bronch (466) → Pneumonia (486) 2,854 2.7E-301
Cataract (366) → Ac bronch (466) 2,749 1.7E-120
Ac bronch (466) → Other diseases of lung (518) 2,728 2.6E-270
Diseases of pancreas (577) → Cholelithiasis (574) 2,660 <4.9E-324
Cataract (366) → Diabetes mellitus (250) 2,636 1.1E-22
Chronic bronchitis (491) → Emphysema (492) 2,619 <4.9E-324