Fig. 1.

Loss of CDK6 kinase activity in mice leads to an improved metabolic profile. a, b Body weight of age-matched male mice on NCD (a) or HFD (b) for a 14-week observation time. HFD commenced at 4 weeks of age. c, d Mass of various fat pads was normalized to body weight of male mice on NCD (c) or HFD (d) at 18 weeks of age. No significant changes were observed in the masses of BAT and livers between WT and K43M mice under NCD and HFD. e, f GTT after 14 weeks on NCD (e) or HFD (f). g, h ITT after 14 weeks on NCD (g) or HFD (h). For a–h, data shown are mean ± S.E. (n = 10 for each group), *p < 0.05, t-test, vs WT. See also Supplementary Figs. 2 and 3