Fig. 5.

Re-expression of CDK6 in mature adipocytes reversed the beneficial metabolic effects observed in KO mice, whereas re-expression of kinase dead CKD6 recapitulates this metabolic profile. a, b Body weight of age-matched male mice on NCD (a) or HFD (b) for 14-week observation time. HFD started at age of 4 weeks. c, d GTT after 18 weeks on NCD (c) or HFD (d). e, f ITT after 18 weeks on NCD (e) or HFD (f). g, h Mass of various fat pads was normalized to body weight of male mice on NCD (g) or HFD (h) at age of 18 weeks. No significant changes were observed in the masses of BAT and livers in those mice under NCD and HFD. For a–h, data are expressed as mean ± S.E. (n = 10 for each group), *p < 0.05, t-test, vs WT-A. See also Supplementary Fig. 3