Duplicates removed	12
Excluded during initial screening (e.g. press releases; news reports; not relevant drug/indication; preclinical study; reviews; case reports; not randomized trial)	215
Excluded during writing (e.g. reviews; duplicate data; small patient number; nonrandomized/phase I/II trials)	21
Cited efficacy/tolerability articles	14
Cited articles not efficacy/tolerability	25
Search Strategy: EMBASE, MEDLINE and PubMed from 1946 to present. Clinical trial registries/databases and websites were also searched for relevant data. Key words were Eculizumab, Soliris, 5G1.1, myasthenia gravis, gMG. Records were limited to those in English language. Searches last updated 26 January 2018