Table 1.

Rank of the proposed LeadOp+R compounds based on the calculated binding energy, inhibition concentration (IC₅₀) of Tie-2 from the literature (Hodous et al., 2007).

Rank	Structure	Inhibition IC50 (nM)
Query		399
38		4
113		30
292		108

All proposed compounds have a lower IC₅₀ value than the query compound and the suggested priority of the three new compounds (out of 631) have a similar trend as the IC₅₀ potency values.