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. Author manuscript; available in PMC: 2018 Mar 10.
Published in final edited form as: Nature. 2016 Nov 16;539(7630):583–587. doi: 10.1038/nature20562

Extended Data Figure 6. The interactions and kinetic properties of the molecular switch/sliding clamp mechanism for E. coli MMR.

Extended Data Figure 6

a, Illustration of the kinetics and diffusion properties of EcMutS. b, Illustration of the kinetics and diffusion of EcMutS with EcMutL. c, Illustration of the kinetics and diffusion of EcMutS, EcMutL and EcMutH. d, Oscillation dynamics of the EcMutS–EcMutL–EcMutH complex (see main text). Coil, 1D-diffusion search along the backbone; dashed straight arrow, rotation-independent 1D-diffusion; black curved arrow, binding; red curved arrow, oscillating complex; dashed curved arrow, binding-dissociation; binding times and ATP (•) are indicated.