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. 2018 Mar 9;18:270. doi: 10.1186/s12885-018-4179-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Immunohistochemical expression of CD63 in glioblastoma

a A distinct cytoplasmic CD63 staining was seen in all tumors (arrow). b A distinct plasma membrane labeling was seen in some biopsies (arrows). c, d In general blood vessels showed a weak CD63 expression, but a more intense expression was found in perivascular tumor cells (d). e Pseudopalisade formations showed an intense CD63 expression. f A few CD63 tumor cells with faint CD63 expression as well as CD63+ pyramidal shaped neurons (arrow) were seen in the tumor periphery. Scale bar: 50 μm (a-d) and 100 μm (e-f)