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. 2018 Mar 9;9:55. doi: 10.1186/s13287-018-0781-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Human amniotic mesenchymal stem cells (hAMSCs) improve the follicle numbers in the ovaries of a natural ovarian aging (NOA) mouse model at four stages. a The number of primordial follicles was counted over 4 weeks after hAMSC transplantation. b The number of primary follicles was counted over 4 weeks after hAMSC transplantation. c The number of secondary follicles was counted over 4 weeks after hAMSC transplantation. d The number of antral follicles was counted over 4 weeks after hAMSC transplantation. All the experiments were repeated three times; the error bars indicate SD. **p < 0.01, ***p < 0.001, versus the NOA group. PBS phosphate-buffered saline