Fig. 3.

H₂S was required to maintain FasL expression in GMSCs. a FasL expression decreased in Cbs^−/− GMSCs compared with control GMSCs as analyzed by western blot analysis. b Cbs^−/− GMSCs induced less T-cell apoptosis compared with control cells. Fas-neutralized antibody treatment attenuated the ability of GMSCs to induce T-cell apoptosis (n = 5). c, d FasL overexpression restored the decreased capacity of Cbs^−/− GMSC-inducing T cells in a cell–cell contact coculture system, but not in a transwell coculture system (n = 5). *P < 0.05, **P < 0.01, ***P < 0.001. Error bars: mean ± SD. All experimental data verified in at least three independent experiments. GMSC gingiva-derived mesenchymal stem cell, FasL Fas ligand, Ab antibody