Table 3.
Change in biomarker concentration per day of NMB in a multivariable linear regression model
| Group | Change in SP-D per day of NMB | Change in VWF per day of NMB | Change in IL-8 per day of NMB | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Estimate | 95% CI | P value | Estimate | 95% CI | P value | Estimate | 95% CI | P value | |
| P/F < 120 + LTVV | −23.7 | −44.8, −2.5 | 0.028 | −33.5 | −60.5, −6.4 | 0.015 | −362.6 | −689.3, −35.9 | 0.030 |
| P/F < 120 + HTVV | 34.1 | 10.4, 57.7 | 0.005 | 8.9 | −21.5, 39.2 | 0.566 | 92.7 | −273.1, 458.5 | 0.619 |
| P/F > 120 + LTVV | 14.6 | −11.9, 41.0 | 0.279 | 11.2 | −22.6, 45.0 | 0.517 | −84.7 | −492.5, 323.0 | 0.683 |
| P/F > 120 + HTVV | 72.3 | 44.6, 99.9 | < 0.001 | 53.5 | 18.1, 88.9 | 0.003 | −370.6 | −56.3, 797.5 | 0.089 |
CI confidence interval, IL interleukin, LTVV low tidal volume ventilation, LTVV low tidal volume ventilation, NMB neuromuscular blockade, P/F arterial oxygen tension/fractional inspired oxygen, SP-D surfactant protein D, VWF von Willebrand factor