Table 1.
Median (IQR) values of biomarkers in 1176 fasting men with no CVD at entry by status defined by type of first event occurring during follow-up
| Biomarker | No event during follow-up | New MI/IHD event during follow-up | New stroke event during follow-up | New CHF event during follow-up | |||||||
| n | Median (IQR) |
n | Median (IQR) |
P | n | Median (IQR) |
P | n | Median (IQR) |
P | |
| Cardiac and vascular | |||||||||||
| Troponin (pg/mL) | 751 | 5.4 (4.3–6.8) | 186 | 6.3 (5.1–7.6) | <0.001 | 125 | 5.4 (4.6–7.3) | 0.37 | 51 | 6.9 (5.2–9.6) | <0.001 |
| BNP (pg/mL) | 743 | 19.9 (12.8–30.2) | 184 | 21.6 (13.1–35.4) | 0.13 | 124 | 23.8 (15.9–41.2) | 0.002 | 53 | 35.5 (20.5–65.0) | <0.001 |
| Inflammatory | |||||||||||
| CRP (mg/L) | 748 | 2.05 (1.07–4.13) | 188 | 2.56 (1.49–4.54) | 0.01 | 127 | 2.31 (1.25–4.05) | 0.19 | 51 | 2.75 (1.57–4.69) | 0.10 |
| IL-6 (pg/mL) | 750 | 2.04 (1.42–3.22) | 188 | 2.07 (1.49–3.27) | 0.33 | 127 | 2.31 (1.63–3.07) | 0.11 | 51 | 2.21 (1.56–3.24) | 0.29 |
| IL-6 receptor (ng/mL) | 751 | 37.8 (30.5–44.9) | 188 | 38.0 (30.8–46.9) | 0.55 | 126 | 37.7 (29.8–45.0) | 0.61 | 51 | 38.0 (28.8–43.7) | 0.62 |
| Lipids | |||||||||||
| Cholesterol (mmol/L) | 781 | 6.0 (5.3–6.8) | 195 | 6.5 (6.0–7.2) | <0.001 | 137 | 6.0 (5.4–6.6) | 0.77 | 54 | 6.2 (5.5–6.9) | 0.50 |
| Triglyceride (mmol/L) | 781 | 1.5 (1.1–2.2) | 195 | 1.7 (1.3–2.4) | <0.001 | 137 | 1.5 (1.1–2.2) | 0.83 | 54 | 1.6 (1.0–2.0) | 0.37 |
| Lp-a (mg/dL) | 743 | 7.5 (3.5–18.5) | 188 | 11.4 (5.1–30.8) | 0.001 | 127 | 7.3 (2.6–30.6) | 0.97 | 51 | 6.6 (2.4–20.1) | 0.42 |
| Adhesion molecules | |||||||||||
| VCAM-1 (ng/mL) | 750 | 1282 (1153–1437) | 188 | 1272 (1106–1463) | 0.68 | 127 | 1317 (1162–1454) | 0.35 | 51 | 1322 (1216–1497) | 0.08 |
| E-selectin (ng/mL) | 751 | 25.8 (19.0–33.4) | 188 | 25.4 (19.0–34.8) | 0.91 | 127 | 27.9 (21.3–37.0) | 0.04 | 51 | 30.2 (20.6–38.6) | 0.16 |
| Liver function | |||||||||||
| Alkaline phosphatase (IU/L) | 776 | 85 (70–102) | 194 | 86 (71–103) | 0.42 | 137 | 92 (74–111) | 0.003 | 54 | 87 (70–105) | 0.60 |
| Aspartate transaminase (IU/L) | 773 | 22 (18–27) | 192 | 21 (18–25) | 0.07 | 137 | 20 (17–25) | 0.001 | 53 | 24 (19–29) | 0.22 |
| Alanine transaminase (IU/L) | 777 | 22 (17–29) | 193 | 23 (16–28) | 0.86 | 137 | 21 (17–26) | 0.40 | 54 | 23 (18–29) | 0.45 |
| Gamma-GT (IU/L) | 781 | 27 (20–42) | 195 | 30 (21–44) | 0.13 | 137 | 28 (20–40) | 0.97 | 54 | 28 (23–38) | 0.41 |
| Glutamate dehydrogenase (IU/L) | 362 | 2.0 (1.2–3.3) | 102 | 2.2 (1.2–3.7) | 0.57 | 65 | 2.0 (1.0–3.3) | 0.94 | 25 | 2.3 (1.0–3.4) | 0.99 |
| Acute phase | |||||||||||
| White cell count (×109/L) | 779 | 5.92 (5.07–7.07) | 196 | 6.41 (5.30–7.43) | 0.006 | 137 | 6.20 (5.13–7.70) | 0.07 | 54 | 6.30 (4.86–7.26) | 0.50 |
| Viscosity (mPa·s) | 776 | 167 (162–173) | 195 | 170 (164–176) | <0.001 | 137 | 169 (163–176) | 0.008 | 54 | 170 (164–180) | 0.03 |
| Fibrinogen (g/L) | 771 | 390 (340–450) | 195 | 410 (360–480) | <0.001 | 136 | 410 (370–470) | 0.02 | 54 | 400 (340–470) | 0.39 |
| Ferritin (ng/mL) | 750 | 112 (64–204) | 187 | 113 (73–171) | 0.94 | 126 | 1166 (67–184) | 0.97 | 51 | 136 (70–216) | 0.63 |
| Leucocyte activation | |||||||||||
| GDF-15 (pg/mL) | 751 | 684 (521–876) | 188 | 717 (571–916) | 0.10 | 127 | 708 (566–931) | 0.07 | 51 | 742 (607–910) | 0.10 |
| PAPP-A (ng/mL) | 749 | 7.12 (5.12–9.26) | 188 | 7.27 (5.23–9.32) | 0.75 | 127 | 7.65 (5.88–9.68) | 0.05 | 51 | 7.80 (6.22–9.40) | 0.08 |
| Renal function | |||||||||||
| Cystatin-C (mg/L) | 748 | 0.83 (0.75–0.92) | 188 | 0.85 (0.77–0.92) | 0.12 | 127 | 0.85 (0.78–0.93) | 0.05 | 51 | 0.87 (0.77–0.96) | 0.15 |
| Creatinine (mg/dL) | 775 | 97 (88–106) | 194 | 97 (88–106)) | 0.49 | 137 | 97 (88–106)) | 0.40 | 53 | 97 (88–106) | 0.53 |
| Insulin resisitance | |||||||||||
| Glucose (mmol/L) | 777 | 5.2 (4.9–5.6) | 195 | 5.4 (5.0–5.9) | 0.02 | 137 | 5.4 (5.0–6.0) | 0.005 | 54 | 5.5 (5.0–5.8) | 0.09 |
| Retinol-binding protein (mg/L) | 750 | 31.6 (26.0–37.9) | 188 | 31.9 (26.1–37.9) | 1.00 | 126 | 29.2 (24.8–34.9) | 0.04 | 51 | 29.4 (24.6–36.0) | 0.06 |
| Fetuin-A (mg/L) | 749 | 256 (218–306) | 188 | 273 (224–321) | 0.16 | 126 | 266 (226–308) | 0.30 | 51 | 265 (236–298) | 0.51 |
| Others | |||||||||||
| Uric acid (mg/L) | 780 | 33 (29–39) | 195 | 33 (29–38) | 0.89 | 137 | 33 (28–38) | 0.43 | 54 | 35 (30–39) | 0.79 |
| Vitamin B6 (nmol/L) | 750 | 40.9 (30.4–56.0) | 184 | 40.3 (29.0–54.5) | 0.41 | 122 | 37.2 (27.3–50.6) | 0.05 | 54 | 37.8 (29.4–51.1) | 0.42 |
P values are for comparisons with the no event group.
BNP, B-type natriuretic peptide; CHF, congestive heart failure; CRP, C reative protein; CVD, cardiovascular disease; GDF-15, growth differentiation factor-15; IHD, ischaemic heart disease; IL, interleukin; Lp-a, lipoprotein-a; MI, myocardial infarction; PAPP-A, pregnancy-associated plasma protein-A; VCAM-1, vascular cell adhesion molecule-1.