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. 2018 Feb 8;4(1):e000628. doi: 10.1136/rmdopen-2017-000628

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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rs4265380 interacts with RP4-799D16.1 (A) Hi-C plot showing the interaction of the RUNX3 bait with different regions within chromosome 1 (with score above 5, in CD14+ monocytes). The location of genes, ENCODE CD14+ monocytes chromatin states, ENCODE histone modification and p300 transcription factor chromatin immunoprecipitation sequencing experiments and rs4265380 position are also shown. The plot has been generated through the International Human Epigenome Consortium database (https://www.chicp.org/chicp)¹⁸. (B) RP4-799D16.1 transcript was measured in primary CD14+ monocytes from 16 patients with ankylosing spondylitis with rs4265380 different genotypes (CC, CT and TT). P values were determined using two-tailed Student’s t-test.