. 2018 Feb 3;4(1):e000606. doi: 10.1136/rmdopen-2017-000606

Table 2.

Key studies and observations used in the design of SEAM-PsA

Study (Reference)	Observation
Methotrexate in Psoriatic Arthritis (MIPA)³	Methotrexate monotherapy at 15 mg/week did not result in statistically significant improvements compared with placebo
Etanercept PsA pivotal phase 3 study^{6 11}	Similar efficacy was demonstrated between etanercept monotherapy and combination therapy with etanercept plus methotrexate
Norwegian Disease-modifying Antirheumatic Drugs Longitudinal Observational Study (NOR-DMARD)⁷ Corrona registry⁸	Combination therapies that are efficacious in patients with RA do not provide similar efficacy in patients with PsA

PsA, psoriatic arthritis; RA, rheumatoid arthritis; SEAM-PsA, Study of Etanercept and Methotrexate in Combination or as Monotherapy in Subjects with Psoriatic Arthritis.