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. 2018 Mar 5;5:18. doi: 10.3389/fcvm.2018.00018

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Copyright © 2018 Katsuumi, Shimizu, Yoshida and Minamino

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Common pathways of cellular senescence. Telomere dysfunction, DNA damage, cellular stress (ROS etc) up-regutate p53/p21, p16 signal and induces cellular senescence.