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. 2018 Mar 5;5:18. doi: 10.3389/fcvm.2018.00018

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Copyright © 2018 Katsuumi, Shimizu, Yoshida and Minamino

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of endothelial senescence in cardio-metabolic disease. Chronological aging induces vascular endothelial cell senescence (EC senescence as characterized with an increase of ROS, p53/p21, p16, SA-β-Gal, inflammatory response, and reduced eNOS/NO level). EC senescence has a pivotal role in the progression of diabetes and heart failure. Exercise has a potential to suppress ECs senescence.