Figure 8.

Comparison of experimental growth rates, biomass yields, and acetate yields to those predicted by three constraint-based modeling approaches: FBA (flux balance analysis), MOMA (minimization of metabolic adjustment), and RELATCH (relative optimality in metabolic networks). Marker colors reflect pathway assignment (wild-type: gray; transporters and phosphoglucomutase: blue; oxidative pentose phosphate pathway: red; non-oxidative pentose phosphate pathway: green; Entner-Doudoroff pathway: orange; upper EMP pathway: purple). Pearson correlation coefficients (ρ) describe the agreement between prediction and measurement. Wild-type data were excluded from this correlation.