. 2018 Feb 25;2018:6823193. doi: 10.1155/2018/6823193

Table 1.

Current competing porcine models of metabolic syndrome.

	Ossabaw pig 3		Göttingen pig 5		Iberian pig^b 4
	Obese group		Obese group		Obese group

Obesogenic diet	2.0% cholesterol, 17% hydrogenated soybean oil, 2.3% corn oil, 0.7% sodium cholate		32% crude fat, 17% protein		Ad libitum: 3.7% saturated fat, 2.8% polyunsaturated fat, 15.1% crude protein

Control diet	Lean group		Lean group		Lean group
Control diet	Standard chow		Standard chow		Standard chow
	Lean (n = 9)	Obese (n = 8)	Lean (n = 6)	Obese (n = 6)	Lean (n = 4)	Obese (n = 6)

Duration	9 weeks		5 weeks		100 days
Weight (kg)	29	45^a ^∗	21	27^a ^∗	209	251^a ^∗
Fasting glucose (mmol/L)	<5.5	<5.5	4.4	4.5	<4.4	<4.4
Fasting insulin (mU/L)	<20	<20	11	14	<1	<1
HOMA-IR	—	—	2.1	2.9	<0.3	<0.3
Insulin AUC^c (mU/L × min)	2579	3811^∗	1923	2895^∗	—	—
Glucose AUC^c (mmol/L × min)	NS	NS	578	636	—	—
Systolic blood pressure (mmHg)	113	137	—	—	150	170^a
Diastolic blood pressure (mmHg)	70	92	—	—	95	115^∗
Mean blood pressure (mmHg)	79	107^∗	—	—	112	137^∗
Triglycerides (mmol/L)	0.42	0.57^∗	0.13	0.24^∗	0.24	0.32^∗
Cholesterol
Total (mmol/L)	4.1	12.4^∗	1.8	2.0	1.7	2.9^∗
HDL (mmol/L)	1.2	1.0^a	0.8	1.0^∗ ^a	0.8	0.72^a
LDL (mmol/L)	2.7	11^∗	—	—	1.2	1.6^∗
LDL/HDL ratio	2.5	11^∗	—	—	1.5	2.3^∗

NS: data not provided but reported as nonsignificant difference. ^aChanges fulfill human criteria of metabolic syndrome. ^bAll data points read from published figures. ^cIVGTT in all but Iberian pig (oral GTT). 60 minutes AUC in Ossabaw pigs and 120 min AUC in Göttingen and Iberian pigs 2 g/kg orally; ^∗ p < 0.05.