Table 3.
Study characteristics of selected studies on short-term and long-term complications after APC treatment.
| Author | Proctitis | Total number of bleeding | Short-term complications | Number of perforations | Long-term complications | Rate of complications (%) |
|---|---|---|---|---|---|---|
| Alfadhli | Prospective | 14 | 2 (vomiting, abdominal cramps, rectal pain, and fever) | 0 | 0 | 14.30 |
| Álvaro-Villegas | Chronic radiation proctitis | 14 | 2 (rectal pain) | 0 | 3 (rectal ulcers) | 35.70 |
| Ben | Hemorrhagic radiation proctitis | 27 | 5 (anal or rectal pain, vagal symptoms, and colonic explosions without perforation in 2 and perforation in 1) | 1 | 0 | 18.50 |
| Canard | Radiation proctitis | 30 | 6 (post treatment pain) | 1 | 1 (extensive necrosis of the lower part of the rectum) | 26.70 |
| Chruscielewska-Kiliszek | Chronic radiation proctitis | 62 | 1 (adynamic ileus) | 0 | 35 (asymptomatic rectal ulcer in 30 and symptomatic rectal ulcers in 5) | 58.10 |
| Chutkan | Proctitis | 12 | 0 | 0 | 0 | 0.00 |
| de la Serna Higuera | Hemorrhagic radiation proctopathy | 10 | 0 | 0 | 0 | 0.00 |
| Dees | Chronic radiation proctitis | 48 | 0 | 0 | 1 (recurrence of rectal bleeding) | 2.00 |
| Fantin | Proctitis | 7 | 0 | 0 | 0 | 0.00 |
| Hortelano E | Chronic radiation proctitis | 30 | 1 (incontinence) | 0 | 1 (rectal ulcer) | 6.67 |
| Kaassis | Proctitis | 16 | 4 (transitory and minimal dysenteric) | 0 | 1 (recurrence of rectal bleeding) | 31.30 |
| Karamanolis | Radiation proctitis | 56 | 1 (colonic explosion without perforation) | 0 | 2 (recurrence of rectal bleeding) | 5.4 |
| Latorre | Chronic radiation proctopathy | 38 | na | na | 0 | 0.00 |
| Lenz | Chronic radiation coloproctopathy | 15 | 4 (anal pain in 2 cases and abdominal discomfort in 1, worsening of bleeding during treatment in 1) | 0 | 2 (tapered feces without stenosis in 1, asymptomatic stenosis in 1) | 40.00 |
| Lpoez | Radiation proctopathy | 19 | 0 | 0 | 1 (recurrence of rectal bleeding) | 5.30 |
| Onoyama | Chronic hemorrhagic radiation proctitis | 24 | 0 | 0 | 0 | 0.00 |
| Rolachon A | Proctitis and proctosigmoiditis | 12 | 0 | 0 | 3 (chronic rectal ulcerations in 2 cases and rectal stenosis in 1 case) | 25.00 |
| Rotondano | Chronic radiation proctopathy | 24 | 5 (mild bloating, cramping, anal pain) | 0 | 1 (rectal stenosis) | 25.00 |
| Sait Dag | Radiation proctitis | 21 | 4 (rectal pain and distension) | 0 | 1 (recurrence of rectal bleeding) | 23.80 |
| Samy | Chronic proctitis | 23 | na | na | 0 | 0.00 |
| Sarah | Proctitis | 11 | 0 | 0 | 7 (rectal stenosis in 2 patients, ulceration in 1, asymptomatic superficial ulceration in 4) | 63.60 |
| Sato | Hemorrhagic radiation proctopathy | 65 | 8 (rectal pain) | 0 | 4 (recurrence of rectal bleeding) | 18.50 |
| Sebastian | Radiation proctopathy | 25 | 0 | 0 | 0 | 0.00 |
| Silva | Proctosigmoiditis | 28 | 3 (transient anal pain) | 0 | 0 | 10.70 |
| Smith | Proctitis | 7 | 0 | 0 | 0 | 0.00 |
| Swan | Chronic radiation proctitis | 49 | 17 (proctalgia in 13 patients, rectal mucous discharge in 4, incontinence in 1, fever in 1, and bleeding in 1) | 0 | 1 (rectal stricture) | 36.00 |
| Takemoto | Hemorrhagic radiation proctopathy | 12 | 0 | 0 | 0 | 0.00 |
| Tam | Proctitis | 15 | 0 | 0 | 2 (rectal stricture) | 13.30 |
| Tjandra | Hemorrhagic proctitis | 12 | 0 | 0 | 0 | 0.00 |
| Venkatesh | Radiation proctitis | 40 | 0 | 0 | 0 | 0.00 |
| Villavicencio | Hemorrhagic radiation proctopathy | 21 | 3 (rectal pain, tenesmus, and/or abdominal distention) | 0 | 1 (recurrence of rectal bleeding) | 19.00 |
| Zinicola | Radiation proctitis | 12 | 0 | 0 | 1 (rectosigmoid stenosis) | 7.10 |