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. 2018 Mar 6;9:192. doi: 10.3389/fphar.2018.00192

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Copyright © 2018 Svobodova, Bhattaracharya, Ivetic, Bendova and Zemkova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of carbenoxolone and other P2 receptor blockers on the circadian rhythmicity of ATP release. (A) Partial inhibitory effect of the pannexin-1 hemichannel blocker carbenoxolone (CBX). (B) Inhibition by the non-specific P2 receptor blocker PPADS. (C) Lack of an effect of the P2X4R-selective antagonist 5-BDBD. (D) Circadian ATP release was significantly decreased by the P2Y1-selective inhibitor MRS2179 (left panel) and potentiated by the P2Y1R-selective agonist MRS2365 (right panel). (E) Summary graph showing the effects of the tested drugs on ATP release at the end of the incubation period. Data are presented as the means ± SEM of three to four experiments. ^**P < 0.01 compared to the control.