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. 2017 Sep 27;98(10):2507–2519. doi: 10.1099/jgv.0.000923

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Fig. 6. — DENV-1 WP 74 infection results in alterations in the levels of cytokines and chemokines in serum. Serum was collected from 6 to 8-week-old AG129 mice (n=5/day) infected with DENV-1 WP 74 or age-matched media-treated controls (n=6). The levels of cytokines (a) and chemokines (b) were quantified from a panel of 23 cytokines using a multiplex bead assay (Bio-Rad, Hercules, CA, USA) following the manufacturer’s protocols. The cytokine abbreviations are as follows: IL, interleukin; KC, keratinocyte chemoattractant; G-CSF, granulocyte colony-stimulating factor; IFNγ, interferon gamma; TNFα, tumor necrosis factor alpha; MCP-1 (CCL2), monocyte chemoattractant protein-1 (CCL3 or 4); MIP, macrophage inflammatory protein; RANTES (CCL5), regulated on activation, normal T cell expressed and secreted; GM-CSF, granulocyte/macrophage colony-stimulating factor. *P<0.01, **P<0.001 (Student's t-test) compared to controls.

Fig. 6. — DENV-1 WP 74 infection results in alterations in the levels of cytokines and chemokines in serum. Serum was collected from 6 to 8-week-old AG129 mice (n=5/day) infected with DENV-1 WP 74 or age-matched media-treated controls (n=6). The levels of cytokines (a) and chemokines (b) were quantified from a panel of 23 cytokines using a multiplex bead assay (Bio-Rad, Hercules, CA, USA) following the manufacturer’s protocols. The cytokine abbreviations are as follows: IL, interleukin; KC, keratinocyte chemoattractant; G-CSF, granulocyte colony-stimulating factor; IFNγ, interferon gamma; TNFα, tumor necrosis factor alpha; MCP-1 (CCL2), monocyte chemoattractant protein-1 (CCL3 or 4); MIP, macrophage inflammatory protein; RANTES (CCL5), regulated on activation, normal T cell expressed and secreted; GM-CSF, granulocyte/macrophage colony-stimulating factor. *P<0.01, **P<0.001 (Student's t-test) compared to controls.