Table 1.
Comparison of anthropometric, biochemical and metabolic data between assessments performed at baseline and following treatment with TU IM testosterone replacement therapy (paired sample t-tests; bold p-values indicate statistical significance)
| Phenotype | Baseline HG group mean (SD) (n = 13) | Follow-up HG group mean (SD) (n = 13) | Paired-sample t-test comparison |
|---|---|---|---|
| BMI (kg m−2) | 38.5 (6.0) | 38.0 (5.5) | 0.18 |
| Age (years) | 49.4 (8.8) | N/A | N/A |
| Body weight (kg) | 120.9 (18.6) | 119.5 (16.3) | 0.26 |
| Fat mass (kg) | 51.2 (15.8) | 47.7 (16.1) | 0.033 |
| Lean mass (kg) | 67.9 (7.0) | 70.8 (6.6) | 0.028 |
| Body fat (%) | 42.2 (7.1) | 39.4 (8.8) | 0.030 |
| BMR (Kcal 5–6 am) | 92.6 (14.7) | 97.0 (13.4) | 0.24 |
| Metabolic rate 21 h (Kcal) | 2316 (353) | 2321 (328) | 0.90 |
| Thermic effect of food (Kcal) | 495 (80) | 498 (73) | 0.78 |
| Hb (g/dl) | 15.2 (1.1) | 15.7 (1.1) | 0.16 |
| ALT (U/l) | 36 (15) | 29 (13) | 0.11 |
| HbA1C (mmol/mol) | 56 (16) | 47 (7) | 0.028 |
| Fasting glucose (mmol/l) | 9.3 (3.3) | 6.8 (1.9) | 0.10 |
| Fasting insulin (pmol/l) | 270 (188) | 240 (133) | 0.51 |
| HOMA2 IR | 5.5 (3.8) | 4.5 (2.4) | 0.32 |
| HOMA %B | 108 (46) | 160 (78) | 0.05 |
| Total cholesterol (mmol/l) | 4.1 (1.0) | 4.0 (0.8) | 0.74 |
| HDL cholesterol (mmol/l) | 1.1 (0.1) | 1.1 (0.2) | 0.19 |
| LDL cholesterol (mmol/l) | 2.4 (1.0) | 2.2 (0.8) | 0.45 |
| Triglycerides (mmol/l) | 1.7 (0.7) | 1.8 (0.9) | 0.61 |
| Adiponectin (pg/ml) | 1520 (461) | 1489 (320) | 0.87 |
| Leptin (pg/ml) | 164 (99) | 144 (99) | 0.31 |
| Estradiol (pmol/l) | 97 (54) | 194 (75) | 0.042 |
| PSA (ng/ml) | 0.8 (0.5) | 1.1 (0.7) | 0.022 |
| Testosterone (nmol/l) | 6.7 (5.9) | 15.2 (6.4) | 0.046 |
| SHBG (nmol/l) | 21.3 (6.9) | 25.0 (7.5) | 0.003 |
| Haematocrit (%) | 45.5 (3.4) | 47.2 (3.3) | 0.19 |
| Haemoglobin (g/dl) | 14.8 (1.3) | 15.3 (1.2) | 0.16 |
| Free androgen index | 28.3 (12.7) | 60.8 (35.5) | 0.01 |