Table 2.
Comparison of anthropometric, biochemical, and metabolic data between assessments performed at baseline for hypogonadal (HG) and eugonadal (EG) groups (independent sample t-tests; bold p-values indicate statistical significance)
| Phenotype | Baseline HG group mean (SD) (n = 13) | Baseline EG group mean (SD) (n = 15) | Independent-sample t-test comparison |
|---|---|---|---|
| BMI (Kg m−2) | 38.5 (6.0) | 36.6 (5.5) | 0.47 |
| Age (years) | 49.4 (8.8) | 50.4 (12.1) | 0.81 |
| Body weight (kg) | 120.9 (18.6) | 110.5 (18.2) | 0.27 |
| Fat mass (kg) | 51.2 (15.8) | 43.9 (17.6) | 0.34 |
| Lean mass (kg) | 67.9 (7.0) | 65.0 (6.1) | 0.33 |
| Body fat (%) | 42.2 (7.1) | 39.1 (9.7) | 0.46 |
| BMR (Kcal 5–6 am) | 92.6 (14.7) | 79.9 (10.8) | 0.040 |
| Metabolic rate 21 h (Kcal) | 2316 (353) | 2065 (287) | 0.12 |
| Thermic effect of food (Kcal) | 495 (80) | 441 (65) | 0.17 |
| ALT (U/l) | 36 (15) | 28 (25) | 0.30 |
| HbA1C (mmol/mol) | 56 (16) | 49.2 (21.5) | 0.33 |
| Fasting glucose (mmol/l) | 9.3 (3.3) | 6.7 (1.0) | 0.11 |
| Fasting Insulin (pmol/l) | 270 (188) | 141 (74) | 0.09 |
| HOMA2 IR | 5.5 (3.8) | 2.7 (1.4) | 0.07 |
| HOMA %B | 108 (46) | 108 (49) | 0.65 |
| Total cholesterol (mmol/l) | 4.1 (1.0) | 4.2 (0.8) | 0.99 |
| HDL cholesterol (mmol/l) | 1.1 (0.1) | 1.2 (0.4) | 0.72 |
| LDL cholesterol (mmol/l) | 2.4 (1.0) | 2.2 (0.8) | 0.64 |
| Triglycerides (mmol/l) | 1.7 (0.7) | 1.5 (0.6) | 0.77 |
| Adiponectin (pg/ml) | 1520 (461) | 2833 (2773) | 0.28 |
| Leptin (pg/ml) | 164 (99) | 99 (72) | 0.17 |
| Estradiol (pmol/l) | 97 (54) | 115 (48) | 0.92 |
| PSA (ng/ml) | 0.8 (0.5) | 2.3 (4.9) | 0.34 |
| Testosterone (nmol/l) | 6.7 (5.9) | 14.2 (5.0) | 0.036 |
| Luteinizing hormone LH (IU/l) | 4.6 (2.6) | 6.4 (3.5) | 0.18 |
| Follicle stimulating hormone FSH (IU/l) | 5.6 (4.7) | 7.9 (5.3) | 0.28 |
| SHBG (nmol/l) | 21.3 (6.9) | 37.8 (19.6) | 0.010 |
| Haematocrit (%) | 45.5 (3.4) | 44.9 (2.1) | 0.79 |
| Haemoglobin (g/dl) | 14.8 (1.3) | 15.0 (1.0) | 0.77 |
| Free androgen index | 28.3 (12.7) | 37.9 (15.6) | 0.14 |