Table 1.

In silico pathway analysis of cellular miRNAs altered by v-miRs.

Viral miRNA (cell type)	Predicted pathways
HSV1 miR-H1 [human oral keratinocytes (HOK)]	Actin cytoskeleton Calcium signaling Focal adhesions MAPK pathway PI3K-Akt signaling pathway Wnt pathway
KSHV K12-3p (HOK)	Focal adhesions pathway Adherens pathway Actin cytoskeleton genes MAPK signaling pathway PI3K-Akt pathway
Human cytomegalovirus (HCMV) UL-70 (HOK)	MAPK gene Focal adhesions pathway Gap junction genes ERB pathway
HSV1 miR-H1 (Mφ)	Calcium signaling pathways Endocytosis pathway MAPK signaling pathway T cell receptor genes Wnt signaling pathway RNA transport genes PI3K-Akt genes TGF-β signaling pathway
KSHV K12-3p (Mφ)	Endocytosis Pathway MAPK Signaling Pathway PIK-Akt Pathway Protein Production in ER RNA Transport Genes Wnt Signaling Pathway
HCMV UL-70 (Mφ)	Apoptosis Chemokine Endocytosis pathway Erb pathway Osteoclast differentiation pathways PI3K-Akt pathway T-cell receptor genes

Cellular miRNAs dysregulated by v-miRs in both HOK and Mφ were analyzed for the identification of cellular pathways. List of top 5–8 pathways are listed.