Table 2.
Results of the neuropsychological evaluation in the pre-HD and manifest HD groups including the Hopkins Verbal Learning Test (HVLT-R), the Mattis Dementia Rating Scale (MDRS), the subtests of the UHDRS-Cognitive score and the Boston Naming Test (BNT).
| Manifest HD | Pre-HD | |
|---|---|---|
| MDRS | 132.5 ± 7.4§ | 141.2 ± 4.6 |
| HVLT-R total recall | 15.4 ± 4.8a§ | 28 ± 5.9 |
| HVLT-R delayed recall | 4.3 ± 2.5ǂ§ | 10 ± 1.4 |
| HVLT-R percentage retained | 66.9 ± 25.5§ | 99.4 ± 23.4 |
| HVLT-R discrimination index | 8.1 ± 4.2§ | 11,6 ± 0,5 |
| Letter fluency (FAS) | 24.4 ± 9.2§ | 43 ± 14.5 |
| Stroop interference | 2.9 ± 4.4§ | 13.8 ± 11.5 |
| Symbol digit code | 28.4 ± 11.2ǂ§ | 51 ± 9.4 |
| BNT | 50.1 ± 3.9§ | 56.7 ± 2.2 |
a
Moderate impairment compared to standardized scores in published norms of the tests (standard score < 30). ǂMild impairment compared to standardized scores (standard score 30–34). § ignificantly different from pre-HD (in pairwise comparisons, p < .05). MDRS = Mattis Dementia Rating Scale; HVLT-R = Hopkins Verbal Learning Test-Revised; BNT = Boston Naming Test.