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. 2018 Mar 6;9:190. doi: 10.3389/fphar.2018.00190

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Copyright © 2018 Liu, Miao, Chen, Wang, Sun and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of abnormally altered components (UCB, unconjugated bilirubin; CA, cholic acid; DCA, deoxycholic acid; LCA, lithocholic acid; CDCA, chenodeoxycholic acid; and UDCA, ursodeoxycholic acid) in ALF mouse serum on the function and expression of P-GP in HCMEC/D3 and MDCK-MDR1 cells, respectively. Cell viability (A,B), rhodamine 123 uptake (C,D), vincristine uptake (E,F), and P-GP expression (G,H) were determined in HCMEC/D3 and MDCK-MDR1 cells after treatment with abnormally altered components for 24 h, respectively. Data are expressed as mean ± SD (n = 4). ^∗P < 0.05, ^∗∗P < 0.01 vs. control.