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. 2018 Mar 6;9:190. doi: 10.3389/fphar.2018.00190

FIGURE 3.

FIGURE 3

The apical–basolateral (AP–BL) and basolateral–apical (BL–AP) apparent permeability coefficients (Papp) of phenobarbital across MDCK type II cells transfected with human P-GP (MDCK-MDR1) (B), BCRP (MDCK-BCRP) (C), and respective MDCKII wild-type (MDCK-WT) (A) cells. Papp of reference substrate rhodamine 123 (P-GP) was tested in MDCK-WT (D) and MDCK-MDR1 (E) cell monolayers. Papp of reference substrate prazosin (BCRP) was tested in MDCK-WT (F) and MDCK-BCRP (G) cell monolayers. Phenobarbital, rhodamine 123, and prazosin concentrations were set to be 10 μM, respectively. Data are expressed as mean ± SD (n = 4). ∗∗P < 0.01 vs. PappAP-BL.