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. 2018 Mar 6;9:190. doi: 10.3389/fphar.2018.00190

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Copyright © 2018 Liu, Miao, Chen, Wang, Sun and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Formation of 1-hydroxylmidazolam from midazolam in hepatic microsomes of control (white bar) and ALF (shaded bar) mice (A). The relative mRNA levels (B) and protein levels (C) of Cyp3a11 in hepatic microsomes of control (white bar) and ALF (shaded bar) mice. Data represent the mean ± SD (n = 6), ^∗P < 0.05, ^∗∗P < 0.01 vs. control mice.