Table 3.

Effect of ALF on rhodamine 123, DNP-SG, and prazosin distribution in plasma and brain.

	Control (n = 6)	ALF (n = 6)
Rhodamine 123
Plasma level (ng/mL)	17.72 ± 3.43	22.31 ± 3.40*
Brain level (ng/g)	2.65 ± 0.70	5.20 ± 1.32**
Brain-to-plasma ratio (mL/g)	0.15 ± 0.02	0.23 ± 0.03**
DNP-SG
Plasma level (μg/mL)	9.22 ± 2.63	11.81 ± 3.13
Brain level (μg/g)	2.26 ± 0.71	1.37 ± 0.34*
Brain-to-plasma ratio (mL/g)	0.25 ± 0.04	0.12 ± 0.02**
Prazosin
Plasma level (ng/mL)	188.32 ± 32.66	146.05 ± 29.86*
Brain level (ng/g)	31.84 ± 4.97	41.96 ± 9.81*
Brain-to-plasma ratio (mL/g)	0.17 ± 0.02	0.29 ± 0.03**
Evens blue
Brain level (ng/mg)	2.35 ± 0.31	2.74 ± 0.46

Data are expressed as mean ± SD (n = 6). ^∗P < 0.05, ^∗∗P < 0.01 vs. control mice.