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. 2018 Mar 6;10:47. doi: 10.3389/fnagi.2018.00047

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Copyright © 2018 Kassubek, Müller, Del Tredici, Hornberger, Schroeter, Müller, Anderl-Straub, Uttner, Grossman, Braak, Hodges, Piguet, Otto and Ludolph.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) 3D-images of tracts of interest. 3D-images of tracts of interest: fasciculus uncinatus, corresponding to bvFTD stage 1; corticostriatal pathway, corresponding to bvFTD stage 2; corticospinal tract (CST) corresponding to bvFTD stage 3, optic radiation, corresponding to bvFTD stage 4; superior cerebellar peduncle as reference path. (B) Longitudinal FA differences in stage-related tract systems. Longitudinal averaged FA differences (baseline—follow-up) in tracts at the group level—*significance.