Table 1.

Neuropsychological outcome measures used in a compassionate use IND trial of DFMO in a single case.

Neuropsychological Domain	Tests Administered
Global cognition	Mini Mental Status Exam (MMSE) (Folstein et al., 1975) Alzheimer's disease assessment scale-cognitive subscale (ADAS-Cog;11 item) (Rosen et al., 1993)
Verbal episodic memory	Logical Memory I (WMS-R) Immediate and Delayed Recall (Wechsler, 1997) International Shopping List Test (ISLT; Cogstate) (Lim et al., 2009)
Visual episodic memory	Groton Maze Learning Test (GMLT; Cogstate) delayed recall (Snyder et al., 2005; Fredrickson et al., 2008)
Language	Category Fluency (animals) (Borkowski et al., 1967)
Executive function	GMLT (Cogstate Ltd.) Learning (Snyder et al., 2005; Fredrickson et al., 2008) One Card-Learning Task (OCL; Cogstate Ltd.) (Maruff et al., 2013) Phonemic Fluency (FAS) (Borkowski et al., 1967; Tombaugh et al., 1999)
Working memory	Groton Maze Learning Test (GMLT; Cogstate Ltd.) (Snyder et al., 2005; Fredrickson et al., 2008) One-back Task (OBK; Cogstate Ltd.) (Maruff et al., 2013)
Processing speed	GMLT Chase Test (Cogstate Ltd.) (Snyder et al., 2005; Fredrickson et al., 2008)
Subjective cognitive complaints	Subjective Cognitive Decline (SCD) (Gifford et al., 2015)
Depression	Geriatric Depression Scale (GDS) (Yesavage and Sheikh, 1986)