Table 2.
Scores on all outcome measures for patient CS, age 74, over 12 month DFMO treatment period.
| Measure | Exam 1 (baseline) | Exam 2 (3 months) | Exam 3 (9 Months) | Exam 4 (12 months) |
|---|---|---|---|---|
| MMSE (/30) | 26 | 26 | 24 | 22 |
| ADAS-Cog (/70) | 30 | 34 | 31 | 33 |
| Logical Memory, Immediate Recall (/25) | 9 | 4 | 6 | 6 |
| Logical Memory, Delayed Recall (/25) | 3 | 3 | 3 | 6 |
| Phonemic Fluency (FAS) | 38 | 41 | 22 | 32 |
| Phonemic Fluency (animals) | 9 | 9 | 5 | 9 |
| GDS (/15) | 4 | 1 | 2 | 2 |
| Subjective Cognitive Decline (/9) | 6 | 6.5 | 4 | 5 |
| Chase Test mps | 0.167 | 0.133 | 0.233 | 0.366 |
| Chase Test total errors | 14 | 11 | 5 | 8 |
| Chase Test feedback errors | 14 | 11 | 5 | 8 |
| GMLT mpsa | 0.162 | 0.195 | 0.131 | 0.187 |
| GMLT total errorsa | 31.67 | 37.75 | 30.00 | 37.00 |
| GMLT feedback errorsa | 13.33 | 18.50 | 14.67 | 19.50 |
| GMLT delayed recall: mps | b | b | b | 0.125 |
| GMLT delayed recall: total errors | b | b | b | 30 |
| GMLT delayed recall: feedback errors | b | b | b | 20 |
| GMLT reverse recall: mps | b | b | 0.141 | 0.163 |
| GMLT reverse recall: total errors | b | b | 30 | 67 |
| GMLT reverse recall: feedback errors | b | b | 12 | 44 |
| One Card Learning: accuracy | 0.964 | 0.891 | 0.904 | 0.785 |
| One Card Learning: total errors | 26 | 32 | 31 | 41 |
| One Back Task: accuracy | 0.860 | 0.747 | 0.927 | |
| One Back Task: total Errors | 6 | 20 | 21 | 18 |
| ISLT Total Learning (3 trials, /36) | c | 15 | 9 | 18 |
| ISLT Delayed Recall (/12) | c | 2 | 1 | 2 |
| Florbetapir PET SUVr | 1.55 | 1.69 |
a
Averaged across 5 learning trials.
b
Patient did not complete for cognitive reasons.
c
Patient did not complete for technological reasons.