Table 2. Genes differentially regulated (>log 2-fold) in the RN6390 essC deletion mutant, sorted by ascending fold change.

Locus ID	Gene name	Fold change	Description	Known regulators
Downregulated genes
SAOUHSC_00262	essC	−29.4	T7SS ATPase EssC
SAOUHSC_02290	–	−7.8	Unknown, hypothetical protein
SAOUHSC_01942	splA	−5.4	Highly specific serine protease specific to S. aureus	Agr (indirect) [60]
SAOUHSC_01944	–	−4.5	Unknown, hypothetical protein
SAOUHSC_02243	lukG	−4.5	Leukocidin-like toxin
SAOUHSC_01941	splB	−4.3	Serine protease SplB	Agr [60]
SAOUHSC_01938	splD	−4.3	Serine protease SplD	Agr [60]
SAOUHSC_01121	hla	−4.1	α-Haemolysin	Agr [61]
Upregulated genes
SAOUHSC_02433	sfaC	4.1	Unknown, hypothetical protein	Fur [62]
SAOUHSC_02865	feoA	4.4	FeoA domain-containing protein
SAOUHSC_00653	fhuB	4.5	Ferrichrome transport permease FhuB	Fur [63]
SAOUHSC_02653	–	4.6	Putative Gcn5-related N-acetyltransferase domain profile
SAOUHSC_02434	sfaB	4.6	Putative siderophore biosynthesis protein	Fur [62]
SAOUHSC_00071	sirC	4.6	Involved in staphyloferrin B transport into the cytoplasm	Fur [64]
SAOUHSC_00246	–	4.7	Putative transmembrane efflux pump protein
SAOUHSC_01089	isdG	4.7	Haem-degrading monooxygenase IsdG	Fur [65]
SAOUHSC_00245	–	5.2	Putative transposase
SAOUHSC_02428	htsB	5.4	Haem transport system permease HtsB	Fur [66]
SAOUHSC_01081	isdA	5.4	Iron-regulated haem-iron binding protein	Fur [65]
SAOUHSC_02719	–	5.5	ABC transporter ATP-binding protein
SAOUHSC_01082	isdC	5.5	Haem transporter IsdC	Fur [65]
SAOUHSC_02654	trxB2	5.5	Thioredoxin reductase TrxB2
SAOUHSC_01085	isdE	5.6	Haem-receptor lipoprotein IsdE	Fur [65]
SAOUHSC_00130	isdI	5.7	Haem-degrading monooxygenase IsdI
SAOUHSC_01086	isdF	6.1	ABC permease IsdF	Fur [65]
SAOUHSC_00131	–	6.1	Putative membrane spanning protein
SAOUHSC_01088	srtB	6.2	Sortase SrtB	Fur [65]
SAOUHSC_01084	isdD	6.2	ATP-hydrolysing and haem-binding protein IsdD	Fur [65]
SAOUHSC_02432	–	6.2	Unknown, hypothetical protein
SAOUHSC_01087	–	6.3	Iron compound ABC transporter permease
SAOUHSC_02655	–	6.3	Unknown, hypothetical protein
SAOUHSC_02245	–	6.5	Unknown, hypothetical protein
SAOUHSC_02435	sfaA	6.7	Putative transporter
SAOUHSC_02554	fhuD2	6.8	Ferric hydroxamate receptor 1 FhuD2	Fur [67]
SAOUHSC_00652	fhuA	7.0	Ferrichrome ABC transporter ATP-binding protein FhuA	Fur [63]
SAOUHSC_00072	sirB	7.4	Involved in staphyloferrin B transport into the cytoplasm	Fur [64]
SAOUHSC_02246	fhuD1	8.0	Iron compound ABC transporter FhuD1	Fur [68]
SAOUHSC_00747	sstB	9.0	Ferrichrome ABC transporter permease SstB	Fur [69]
SAOUHSC_00748	sstC	9.1	Ferrichrome ABC transporter ATP-binding protein SstC	Fur [69]
SAOUHSC_02430	htsA	10.5	Haem transport system lipoprotein HtsA	Fur [66]
SAOUHSC_00746	sstA	10.9	Ferrichrome ABC transporter permease SstA	Fur [69]
SAOUHSC_00074	sirA	16.3	Receptor component of staphyloferrin B	Fur [64]