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. 2018 Mar 6;9:157. doi: 10.3389/fphys.2018.00157

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Copyright © 2018 Ma, Seifi, Papanikolaou, Brown, Swinny and Lewis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TWIK-1 and TASK-2 channels are distributed in myenteric plexus inhibitory neurons and longitudinal smooth muscle layers of the mouse ileum and colon. Panels show overlays of cell specific markers (green) and individual K_2P channel markers (red) throughout. (A1,B1) show overlays for NOS immunoreactive myenteric plexus neurons and the TWIK-1 channel in ileum and colon respectively. TWIK-1 labeling was cytoplasmic and can be observed in both NOS-positive and NOS-negative enteric neurons. Within the longitudinal smooth muscle layer, TWIK-1 channels were distributed in α-actinin-immunopositive smooth muscles in both ileum (A2) and colon (B2). (C1,D1) show overlays for NOS immunoreactive myenteric plexus neurons and the TASK-2 channel in ileum and colon respectively. TASK-2 displayed cell membrane labeling of NOS-negative cell bodies and axons. Immunoreactivity for the TASK-2 channel was not detectable in α-actinin immunopositive longitudinal smooth muscle cells in either mouse ileum (C2) or colon (D2). Scale bars represent 10 μm.