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. 2018 Mar 6;9:157. doi: 10.3389/fphys.2018.00157

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Copyright © 2018 Ma, Seifi, Papanikolaou, Brown, Swinny and Lewis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TREK-2 channels are expressed in myenteric plexus (MP) neurons of both mouse ileum and colon. (A,C3) (ileum) and (B,D3) (colon) show overlays of cell specific markers (green) and the TREK-2 channel marker (red). For clarity, (C1,C2) (ileum) and (D1,D2) (colon) show individual images from corresponding positive merges in enteric neurons. Within the longitudinal smooth muscle (LM) layer, the TREK-2 channel signal was weak and barely detectable in α-actinin immunopositive smooth muscle cells in both ileum (A) and colon (B). (C3,D3) show overlays for NOS immunoreactive myenteric plexus neurons and the TREK-2 channel in ileum and colon respectively. TREK-2 channels appear to be distributed in both NOS-positive and NOS-negative enteric neurons. Scale bars represent 10 μm (A,B) and 20 μm (C1–C3,D1–D3).