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. 2018 Mar 6;9:157. doi: 10.3389/fphys.2018.00157

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Copyright © 2018 Ma, Seifi, Papanikolaou, Brown, Swinny and Lewis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation of mechano-gated K_2P channels by Riluzole and BL-1249 reduces the force but not frequency of spontaneous contractions in mouse ileum and colon. Spontaneous contractions were recorded in the presence and absence of 100 μM Riluzole (A,B) and 30 μM BL-1249 (C,D) in ileum (left) and colon (right) as indicated. Upper panels, representative traces show the effects of 100 μM Riluzole on the spontaneous contractile responses obtained from mouse ileum (A1) and colon (B1). Arrows signify reduction in basal tone. Mean data for force of contraction and frequency is displayed in chart form below the corresponding traces for ileum (A2,A3) and for colon (B2,B3). Lower panels, representative traces show the effects of 30 μM BL-1249 on the spontaneous contractile responses obtained from mouse ileum (C1) and colon (D1). Arrows signify reduction in basal tone. Mean data for force of contraction and frequency is displayed in chart form below the corresponding traces for ileum (C2,C3) and for colon (D2,D3). For traces, scale bars represent 0.2 g (vertical) and 30 s (horizontal) for (A1,C1), and 0.1 g (vertical) and 30 s (horizontal) for (B1,D1). For bar charts, error bars represent standard deviation (SD); n = 6 animals. ^*P < 0.05, ^**P < 0.01, paired t-test.